This drug is only used in cases with severe respiratory depression or cardiovascular complications. Recently we found that intramuscular physostigmine and haloperidol improved several symptoms of acute PCP intoxication as measured by the Brief Psychiatric Rating Scale (BPRS). The antidote for an overdose of diazepam (or any other benzodiazepine) is flumazenil (Anexate). They help to reverse the sedative effect of benzodiazepines and help an unconscious person regain consciousness or prevent recurrence of unconsciousness or coma. Although diazepam, haloperidol, and chlorpromazine have been reported to improve the agitation and psychotic symptoms caused by PCP, the therapeutic efficacy of these agents has rarely been documented with objective clinical measures. Diazepam is a prescription medication used to treat anxiety, muscle spasms, seizures. Benzodiazepine toxicity antidotes have a structure similar to benzodiazepines hence, they compete with benzodiazepines to bind to the receptors. However, there is no known specific antidote for PCP toxicity. that of lorazepam and diazepam and a more prolonged duration of action than diazepam. Management of convulsive status epilepticus in children. Clinical trials suggest that diazepam is more efficacious in procedural.

5. Diazepam has a rapid onset of action and short duration of effect with one-time dosing. Other methods of identification have also been described (e.g. There is general agreement that the treatment of PCP intoxication includes support of vital functions and acidification of the urine. 5.2 Methods for identification of antidote A solution of 10 mg diazepam in 3 mL sulphuric acid shows a green-yellow fluorescence under ultraviolet light (365 nm) (British Pharmacopoeia, 1988). Similarly, PCP intoxication in man can present with diverse symptoms: schizophrenia-like delusions and hallucinations mania violence, dyskinetic, catatonic, or stereotyped movements hypertension and coma. Antihistamines in cough and cold remedies. Selective serotonin reuptake inhibitors (SSRIs) for depression. Phencyclidine (PCP), a widely abused drug currently, has multiple pharmacological actions, including psychotomimetic, anesthetic, sympathomimetic, anticholinergic, and dopaminergic. Monoamine oxidase inhibitors (MAOIs) for depression.

Antidote for diazepam