DIM DIINDOLYLMETHANE FULL
DIM DIINDOLYLMETHANE TRIAL

DIM DIINDOLYLMETHANE TRIAL

In a clinical trial on 18 women with a mutation that increases the risk of breast cancer (BRCA1), oral DIM activated the mutated gene, possibly helping prevent breast cancer. īoth DIM and I3C reduced the risk of breast cancer by activating a pathway that prevents the formation of active estrogen hormones (estrone oxidation to 2-hydroxyestrone) in 4 clinical trials on almost 200 women.

This effect may be due to the anti-estrogenic effect of I3C. Breast CancerĪ meta-analysis of 13 studies and almost 19,000 women associated the intake of cruciferous vegetables such as broccoli, Brussels sprouts, and cabbage with a reduced incidence of breast cancer. In cell-based studies, DIM prevented the growth of cervical cancer cells, promoted their death, and increased their sensitivity to radiotherapy. It also improved abnormal cell growth on the lining of the vulva (vulvar intraepithelial neoplasia) in another trial on 12 women. Its precursor I3C (given by mouth) improved this condition but didn’t prevent HPV infections in a clinical trial on 30 women. Intravaginal DIM suppositories were more effective in another trial on 78 women. However, it failed to resolve this condition and prevent HPV infections in another trial on over 500 women.

In a clinical trial on 64 women with abnormal cell growth on the cervical lining that may develop into cervical cancer (cervical intraepithelial neoplasia I-II), oral DIM improved the lesions and reduced the need for surgery. Remember to speak with a doctor before taking DIM and never use it as a replacement for approved medical therapies. There is insufficient evidence to support the use of DIM for any of the below-listed uses. The following purported benefits are only supported by limited, low-quality clinical studies and animal and cell-based research. Reported to cause male infertility in rats.Insufficient evidence for all potential benefits.May help prevent respiratory papillomatosis recurrence.Ĭurrently, DIM and I3C are used as an add-on therapy in people with a rare respiratory disease caused by the HPV (respiratory papillomatosis) to prevent its recurrence after surgery. The US National Cancer Institute has carried out several pilot trials of DIM as a therapeutic agent for numerous forms of cancer. DIM is one of the most promising anti-tumor agents derived from these vegetables. Įpidemiologic evidence suggests that high dietary intake of Brassica vegetables such as broccoli, cabbage, and Brussels sprouts protects against multiple types of cancer. Read on to learn more about DIM, its potential health benefits, and side effects.ĭiindolylmethane (DIM) is the main metabolite of indole-3-carbinol (I3C), which is a substance with potential anticancer, anti-inflammatory, and chemopreventive properties. Traditionally used as an add-on to prevent the recurrence of a rare respiratory disease, this compound is now being investigated as a cancer-preventing agent.

DIM DIINDOLYLMETHANE FULL

A plus sign next to the number “” means that the information is found within the full scientific study rather than the abstract.ĭiindolylmethane (DIM) is a natural substance found in vegetables like broccoli, cabbage, and cauliflower. Note that each number in parentheses is a clickable link to peer-reviewed scientific studies. If you feel that any of our content is inaccurate, out-of-date, or otherwise questionable, please leave a comment or contact us at Our goal is to not have a single piece of inaccurate information on this website. They are continually monitored by our internal peer-review process and if we see anyone making material science errors, we don't let them write for us again. Our science team must pass long technical science tests, difficult logical reasoning and reading comprehension tests. Our science team is put through the strictest vetting process in the health industry and we often reject applicants who have written articles for many of the largest health websites that are deemed trustworthy. Our team comprises of trained MDs, PhDs, pharmacists, qualified scientists, and certified health and wellness specialists.Īll of our content is written by scientists and people with a strong science background. We are dedicated to providing the most scientifically valid, unbiased, and comprehensive information on any given topic. We believe that the most accurate information is found directly in the scientific source. SelfHacked has the strictest sourcing guidelines in the health industry and we almost exclusively link to medically peer-reviewed studies, usually on PubMed.

Dim diindolylmethane